The Kenya international has agreed to join former boss Mauricio Pochettino in north London on a five-year contract
The midfielder becomes the club's first signing of the summer as they look to reinforce their squad for another Premier League title tilt after finishing third last season.
It is not the first time that Spurs have shown an interest in Wanyama after they failed to convince the south-coast club to sell one of their star players last summer, a decision that reaped rewards as he helped the Saints claim sixth place, guaranteeing Europa League football
However, with only one year left on his contract, Southampton have decided to cash in on the 24-year-old
Press Association Sport understands Tottenham will pay around £9million up front for Wanyama, but the deal could reach almost £12m if additional clauses are met.
Wanyama made 85 league appearances for the south-coast club, scoring four goals
Wanyama, who moved to Southampton from Celtic in 2013, paid tribute to the club's supporters on his personal website.
"I write to you with a heavy heart to announce that I will be leaving Southampton Football Club," he said in an open letter
"As you can imagine it is very emotional for me to say goodbye to the club that gave me the chance to be the first Kenyan to play in Premier League.
"Firstly, I would like to thank the most important part of every club, the fans
It took a while for me to win you all over but I can truly say that with your support and affection I have grown as a player and a person.
"You guys have always been there to lift us up when we were down, and to celebrate with us when we were playing well
I feel really proud that I got the opportunity to wear the Southampton shirt.
"I will never forget my time in Southampton Football Club, I will keep the club forever in my heart."
Source : PA
Source: PA