Swindon will be without striker Elliot Benyon, who has been suffering with illness and a hamstring injury.
Fellow striker Mike Grella could make his debut for the club after joining on loan from Leeds.
Swindon Town boss Danny Wilson told BBC Radio Wiltshire: "There is an enormous amount of pressure on them this year to do well and get promoted.
"We're hopeful that we can go down there and cause them some problems so we'll go down there with no fear.
"I feel for Plymouth. I know Peter Reid well. From our point of view though we have to take advantage of it now. But they will not lie down and we know that."
Source: BBC Sport
Source: BBC Sport