Southampton will be keen to end the season on a high as they play their final home game of 2021/22 on Tuesday night.
But Liverpool are arguably the toughest opposition that Ralph Hasenhuttl's Saints could ask for at this stage, particularly as they have been in rotten form since February finished.
Here's a look at the starting XI the boss could pick...
Southampton predicted lineup vs Liverpool (4-4-2)
Southampton need Mohammed Salisu back in top form | Marc Atkins/GettyImages
GK: Alex McCarthy - Fraser Forster is back in training this week but it is unlikely that he would go straight back into the team for this one.
RB: Kyle Walker-Peters - Has made the switch back over to the right since Tino Livramento's season was ended with injury.
CB: Jan Bednarek - The Pole has started every Premier League game since Christmas.
CB: Mohammed Salisu - Capable of being one of the best centre-backs in the Premier League on his day but hasn't been in the best of form and was briefly dropped in April.
LB: Romain Perraud - On the bench more than he might have expected this season but this stands to be his sixth consecutive Premier League start.
RM: Nathan Redmond - Back in the starting lineup in recent weeks following an enforced spell out. Still looking for his first Premier League goal of the season.
CM: James Ward-Prowse - Set-pieces could be a way for Southampton to do some damage, especially if Virgil van Dijk isn't risked for Liverpool.
CM: Oriol Romeu - Protecting the back four is going to be a crucial part of the game.
LM: Mohamed Elyounoussi - Must remember his defensive duties to try and limit the potential impact of Trent Alexander-Arnold on that side.
ST: Che Adams - Yet to add to his Premier League goal tally since a flurry in February.
ST: Armando Broja - Depending on how the summer unfolds, there is a real chance that this will be his final game at St Mary's as a Southampton player.