Right-back Butterfield has recovered from a calf injury and winger Gobern is finally fit after a hip operation.
Manager Nigel Adkins will definitely make at least one change to his squad after winger Jason Puncheon agreed a surprise loan switch to Millwall.
Alex Chamberlain played 45 minutes for England's Under-18s in midweek and came through unscathed so he should keep his place in the starting line-up.
But Adkins might be tempted to make changes elsewhere after the defeat at Carlisle last week as Saints look for a sixth straight home win.
Lee Barnard could line up alongside Rickie Lambert in attack after starting on the bench at Brunton Park.